Stem cell research breakthrough?

There has been a lot of hoopla and news coverage recently about the results, from teams in Japan and the USA, who used chemical manipulation to produce cells that resemble stem cells. Many groups that oppose the use of embryos in research have proclaimed that the new results mean that there is no longer any valid reasons for using stem cells derived from embryos. They are mistaken for several reasons (ignoring the fact that they opposed the research using embryos anyway).

The results from the latest research do not equate to a medical breakthrough (as some have claimed). What has been published are the results of research on using transcription factors to reprogram skin cells into a state that resemble a stem cell. However both groups used viruses as the vector to introduce the genes to produce the transcription factors into the cells. It’s very unlikely that virally modified cells will be permitted for use in human trials and treatments. So the current research will not be directly translatable into human treatments. More work will be required to find other ways to introduce the transcription factors. Also the fact that the resultant cells resemble stem cells does not mean that they are stem cells. There could be biochemical limitations and side effects that have still to be discovered.

Talk of the end of research using embryonic stem cells is premature. We need to pursue all lines of research, including using embryonic stem cells. Given that many embryos are left over after human fertilisation, and that these will be discarded anyway, then I can’t see what the problem is with using them for research. If we accept the processes that produce the embryos (and we should) then simply discarding the unused ones when they could be used for research is just daft.

All avenues of research need to be kept open and funded in this area. We don’t know which technique will prove to be the best. As Einstein once said:

If we knew what we were doing, it wouldn’t be called research, would it?

To paraphrase. If we knew the best outcome then we could pick the research line that leads to it. But we don’t, so we have to research on all fronts. And that includes using embryonic stem cells and other techniques like nuclear transfer and animal/human hybrid cells. Plus any other techniques that researchers haven’t thought off yet.